Protein Related to DAN and Cerberus (PRDC) is a BMP Antagonist that Participates in Ovarian Paracrine Regulation
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Protein related to DAN and cerberus is a bone morphogenetic protein antagonist that participates in ovarian paracrine regulation.
Bone morphogenetic proteins (BMPs) are important for body patterning and morphogenesis, whereas several BMP antagonists regulate the functions of BMPs during embryonic development and tissue differentiation. Protein related to DAN and cerberus (PRDC) is a secreted protein with a cystine knot structure identified by gene trapping in embryonic stem cells. Although PRDC shows sequence homology wit...
متن کاملStructure of protein related to Dan and Cerberus: insights into the mechanism of bone morphogenetic protein antagonism.
The bone morphogenetic proteins (BMPs) are secreted ligands largely known for their functional roles in embryogenesis and tissue development. A number of structurally diverse extracellular antagonists inhibit BMP ligands to regulate signaling. The differential screening-selected gene aberrative in neuroblastoma (DAN) family of antagonists represents the largest group of BMP inhibitors; however,...
متن کاملPRDC regulates placode neurogenesis in chick by modulating BMP signalling.
The epibranchial placodes generate the neurons of the geniculate, petrosal, and nodose cranial sensory ganglia. Previously, it has been shown that bone morphogenetic proteins (BMPs) are involved in the formation of these structures. However, it has been unclear as to whether BMP signalling has an ongoing function in directing the later development of the epibranchial placodes, and how this sign...
متن کاملXenopus Dan, a member of the Dan gene family of BMP antagonists, is expressed in derivatives of the cranial and trunk neural crest
Dan is the founding member of the Dan family of secreted cytokines. All members of this family--which includes Gremlin, Cerberus, Dante, PRDC, and several genes identified as expressed sequence tags in the mouse--characterized to date have been shown to antagonize signaling by the bone morphogenetic protein (BMP) family. During mouse embryogenesis, Dan is expressed in a restricted and dynamic p...
متن کاملCerberus-like is a secreted BMP and nodal antagonist not essential for mouse development.
Mouse cerberus-like (cer-l) is a member of the Cerberus/Dan family of secreted factors. As other members of this family of proteins, Cer-l functions in the extracellular space, inhibiting signaling molecules. Here we show that the neural-inducing and mesoderm-inhibiting activities of Cer-l result from specific binding to BMP and Nodal molecules, respectively. These properties resemble the ones ...
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تاریخ انتشار 2004